By Prof. Antonio Vidal-Puig MD, PhD, FRCP (auth.), Matej Orešič, Antonio Vidal-Puig (eds.)
The goal of this ebook is to supply the objective viewers, particularly scholars of drugs, Biology, platforms Biology and Bioinformatics, in addition to skilled researchers in study fields proper to metabolic syndrome (MetS) with an summary of the demanding situations and possibilities in platforms biology and the way it may be used to take on MetS. particularly, the goals are: (1) to supply an creation to the main organic techniques curious about the pathophysiology of MetS; (2) by utilizing particular examples, supply an advent to the newest applied sciences that use a structures biology method of examine MetS; and (3) to offer an summary of the mathematical modeling ways for learning MetS.
The basically written chapters by way of prime specialists within the box offers precise descriptions an important for the original place of this ebook and its specialize in the appliance of platforms biology to take on particular pathophysiologically proper facets of MetS and offers a helpful functional consultant to this study community.
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Extra info for A Systems Biology Approach to Study Metabolic Syndrome
Hepatic regulation of glucose and lipid homeostasis is under the control of a complex system of hormones, transcription factors, and signaling pathways. Hepatic steatosis is a condition characterized by an increased amount of fat in the liver, mainly in the form of triglycerides, in a quantity greater than 5 % of liver weight, or histologically deﬁned when 5 % or more of hepatocytes contains visible intracellular triglycerides, that cannot be attributed to alcohol consumption. Fatty liver is closely related to impairment in glucose, fatty acid, and lipoprotein metabolism, and it is now widely recognized as the hepatic manifestation of the Metabolic Syndrome.
9). Gut microbiota is sensitive to environmental factors including the diet and can be considered as a ‘mediator’ between the environment and host biology. Gene products such as proteins regulate many biological processes in the cells including the biochemical networks involving metabolites. Small changes in enzyme concentrations and fluxes through their pathways may produce large changes in the 2 Systems Biology in Human Health and Disease 21 Fig. 3 Factors influencing the metabolome and proteome and the key analytical platforms for systems biology to study health and disease.
1989; Pullinger et al. 1989). Thus, a state of hyperinsulinemia may cause an impaired ApoB-100 synthesis and consequent accumulation 36 S. D’Amore et al. of TGs within hepatocytes. Impaired secretion of VLDL may also be secondary to a decreased activity of MTP, which is essential for the formation of VLDL, packaging TGs with ApoB. Polymorphisms or high-fat diet-induced methylation of MTP are associated with a decreased MTP activity and enhanced TG accumulation in the liver (Chang et al. 2010; Namikawa et al.