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By Frank J. Dixon (Ed.)

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1977). Findings similar to these have been obtained by several laboratories using the same or other antiidiotypes specific for T15, as well as antiidiotypes against other dominant CLONOTYPE REPERTOIRE OF B CELL SUBPOPULATIONS v) m z- 53 40 30 20 10 ID c 2 0 60 50 40 30 20 10 50 75 100 125 150165 180 .. 4. Age-dependent expression of T15' clones in anti-PC response of normal (A) and suppressed mice (B). Columns represent the total response in terms of PC-specific clones/106 B cells for individual donor mice.

D. ENVIRONMENTAL DOWN-REGULATION IN CLONOTYPE REPERTOIREEXPRESSION In contrast to the lack of evidence for environmental participation in either repertoire diversification or the up-regulation of the frequency of B cells of predominant clonotypes, there are now several examples wherein the frequency of mature splenic B cells of a given specificity or clonotype subset is significantly lower than anticipated from the normalized frequency of cells of the same specificity or clonotype subset present in the sIg- bone marrow precursor cell pool.

First, the demonstration that B cells are expressed as clones implies that the repertoire of any given mouse would be substantially smaller than the total number of B cells (approximately 2 x 10') present in the reticuloendothelial system of CLONOTYPE REPERTOIRE OF B CELL SUBPOPULATIONS 33 that individual. For example, if the average clone size is lo2,then any mouse would have 2 X lo6different clonotypes within its mature B cell pool. Furthermore, since the estimated number of newly generated B cells per day is approximately 5 x 10' (Osmond, 1986; Osmond and Nossal, 1974) and if B cells are expressed as clones, then it may be anticipated that fewer than loEdifferent clonotypes could be expressed per day in a mouse.

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